Plant Transcription Factor Database
Previous version: v3.0
Solanum pennellii
M-type_MADS Family
Species TF ID Description
Sopen01g011160.1M-type_MADS family protein
Sopen01g011170.1M-type_MADS family protein
Sopen01g011170.2M-type_MADS family protein
Sopen01g024030.1M-type_MADS family protein
Sopen01g025960.1M-type_MADS family protein
Sopen01g025980.1M-type_MADS family protein
Sopen01g026420.1M-type_MADS family protein
Sopen01g026510.1M-type_MADS family protein
Sopen01g026520.1M-type_MADS family protein
Sopen01g028210.1M-type_MADS family protein
Sopen01g028340.1M-type_MADS family protein
Sopen01g030700.1M-type_MADS family protein
Sopen01g030710.1M-type_MADS family protein
Sopen01g033630.1M-type_MADS family protein
Sopen01g033640.1M-type_MADS family protein
Sopen01g033650.1M-type_MADS family protein
Sopen01g038810.1M-type_MADS family protein
Sopen01g041630.1M-type_MADS family protein
Sopen01g044720.1M-type_MADS family protein
Sopen01g045900.1M-type_MADS family protein
Sopen01g046240.1M-type_MADS family protein
Sopen01g046270.1M-type_MADS family protein
Sopen01g048550.1M-type_MADS family protein
Sopen01g049000.1M-type_MADS family protein
Sopen01g049030.1M-type_MADS family protein
Sopen01g049040.1M-type_MADS family protein
Sopen01g049050.1M-type_MADS family protein
Sopen02g010260.1M-type_MADS family protein
Sopen02g010270.1M-type_MADS family protein
Sopen02g010870.1M-type_MADS family protein
Sopen03g006640.1M-type_MADS family protein
Sopen03g015140.1M-type_MADS family protein
Sopen03g034910.1M-type_MADS family protein
Sopen03g038500.1M-type_MADS family protein
Sopen04g014010.1M-type_MADS family protein
Sopen04g018160.1M-type_MADS family protein
Sopen04g024370.1M-type_MADS family protein
Sopen04g024410.1M-type_MADS family protein
Sopen04g025630.1M-type_MADS family protein
Sopen04g026820.1M-type_MADS family protein
Sopen04g030400.1M-type_MADS family protein
Sopen05g008160.1M-type_MADS family protein
Sopen05g011240.1M-type_MADS family protein
Sopen05g028010.1M-type_MADS family protein
Sopen05g028030.1M-type_MADS family protein
Sopen05g030350.1M-type_MADS family protein
Sopen06g011330.1M-type_MADS family protein
Sopen06g014200.1M-type_MADS family protein
Sopen06g014360.1M-type_MADS family protein
Sopen06g014530.1M-type_MADS family protein
Sopen06g019750.1M-type_MADS family protein
Sopen06g019860.1M-type_MADS family protein
Sopen06g027600.1M-type_MADS family protein
Sopen07g009260.1M-type_MADS family protein
Sopen07g009270.1M-type_MADS family protein
Sopen07g022640.1M-type_MADS family protein
Sopen07g026330.1M-type_MADS family protein
Sopen07g026340.1M-type_MADS family protein
Sopen08g020300.1M-type_MADS family protein
Sopen09g025050.1M-type_MADS family protein
Sopen10g005940.1M-type_MADS family protein
Sopen10g005960.1M-type_MADS family protein
Sopen10g006210.1M-type_MADS family protein
Sopen10g007120.1M-type_MADS family protein
Sopen10g007160.1M-type_MADS family protein
Sopen10g022550.1M-type_MADS family protein
Sopen10g022580.1M-type_MADS family protein
Sopen11g010600.1M-type_MADS family protein
Sopen11g010690.1M-type_MADS family protein
Sopen11g020770.1M-type_MADS family protein
Sopen11g021030.1M-type_MADS family protein
Sopen11g026860.1M-type_MADS family protein
Sopen11g028510.1M-type_MADS family protein
Sopen12g002030.3M-type_MADS family protein
Sopen12g007870.1M-type_MADS family protein
Sopen12g007920.1M-type_MADS family protein
Sopen12g007950.1M-type_MADS family protein
Sopen12g007960.1M-type_MADS family protein
Sopen12g025810.1M-type_MADS family protein
Sopen12g029630.1M-type_MADS family protein
Sopen12g029850.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513